Decline in skeletal muscle mitochondrial function with aging in humans
While we know that skeletal muscle declines with age (a condition referred to as sarcopenia) but the exact mechanism has not been pinned down. Less building of muscle? Increased breakdown?
This article points to my particular “demise of Western civilization as we know it” reason which is oxidative stress and mitochondrial dysfunction. While my wife does not enjoy my deep discussions of mitochondria oxidative phosphorylation over dinner, when my “mitochondrial dysfunction as the root of all evil” book hits the shelves as a bestseller I’ll be able to stick my tongue out at her…
