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Cholesterol
CRP–Mediated Low Density Lipoprotein Uptake by Macrophages – (03-22-01)
James Bogash
CRP–Mediated Low Density Lipoprotein Uptake by Macrophages
I may need to clarify what this article is talking about. First, it is current theory that macrophages become foam cells once they take up LDL cholesterol from the bloodstream. These foam cells are what lead to the buildup of plaque on the arteries. This article is suggesting that CRP (a marker of chronic inflammation) increases the attraction (“opsonizes”) between the LDL and the macrophages. Low level chronic inflammation can come from so many different sources; and can in turn lead to a multitude of chronic diseases.
Circulation — Abstracts: Zwaka et al. 103 (9): 1194
