Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS Despite reading the ads and articles you see everywhere, the ONLY approach that has been shown to improve lifespan in mammals is calorie restriction without nutrient restriction. Period. However, the pharmaceutical companies are looking for what physiological pathways are triggered with caloric restriction so […]
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents I’ve continued to say that mitochondrial dysfunction is the root of all evil, and have yet to see any studies that convince me otherwise. This article finds that mitochondrial function is reduced by 60% IN THE CHILDREN […]
Mitochondrial dysfunction and migraine: evidence and hypotheses Ok–so some still consider it a hypothesis. But once I get my book together (titled: Mitchondrial Dysfunction as the Root of All That is Evil in Chronic Diseases) everyone will consider it fact. This model fits very well into migraine but leaves a big gaping problem. Mitochondrial dysfunction […]
The Pathobiology of Diabetic Complications Well, I need to just wrap it all up right here. For those of you who’s eyes glaze over as I talk about mitochondrial dysfunction being the root of all that is evil in today’s chronic diseases (my wife just rolls her eyes now–she stopped throwing stuff sometime last year…), […]
Is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death? Any regular readers of the updates know my position on neurodegenerative disorders, and the research continues to support this position. I do, however, wonder how long it really will be before clinicians in neurology begin to pick up on the concept […]
