Suppressed Bone Turnover by Long-Term Bisphosphonate Treatment Accumulates Microdamage but Maintains Intrinsic Material Properties in Cortical Bone of Dog Rib
Sorry for the long title, but this article adds more weight to the concern (in my book, at least) of what exactly biphosphonates (i.e. Fosamax) do to bone.
This study found that micro-damage in bone that occurs with everyday use (this damage and healing is what builds stronger bones with weight bearing exercise) is NOT fixed on these drugs but just kind of hangs around.
In compensation, however, the bones get thicker. This is were the idea that denser is not always better has some viability. Are thicker bones that cannot respond well to certain forces placed them really better?