Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction
As much as I consider insulin resistance to be a devastingly unrecognized problem in today’s society, the truth is that mitochondrial dysfunction is the underlying cause of IR.
This study is just one more in the growing collection supporting the concept that defects in a muscle cell’s ability to generate energy and protect against energy generation predispose IR. It is likely that too much glucose in the cell causes the cell to back off on energy production in an attempt to protect itself, starting the cycle. Luckily, lifestyle changes targeted for helping w/ IR are the very same that help mitochondria function better. Funny how that works out.