Metformin on homocysteine, folate and vitamin B12 in type 2 diabetes
This study found that metformin lowered folate and B12 levels with subsequent elevation of homocysteine. This is, of course, of concern. Considering diabetes’ strong predilection for CVD, supplementation of B12 and folic acid should be standard with metformin use (heck…even without metformin as well…). Considering that metformin is being used with increasing frequency for polycystic ovaries, this is another condition that supplementation should be included.