Risk of coronary artery disease associated with initial sulphonylurea treatment of patients with type 2 diabetes
Ok, so the TZDs for diabetes (i.e. Avandia, Actose) have been giving a black box warning for causing heart disease (the number one cause of death in diabetics, I might add). So let’s use the sulfonylureas, right? Well, they’re known to actually damage the beta cells of the pancreas–the very cells we want to protect!!. And, if that wasn’t bad enough, here we see more than a doubling of risk of heart disease with some of the older drugs in this class. Man…if I was an endocrinologist that really wanted to help my patients–I’d burn the prescription pad and open a gym.