Why do COX-2 inhibitors increase risk of cardiovascular events?
This article nicely reviews potential mechanisms for the increase in cardiovascular events seen with higher frequency in users of these new “superdrugs.” Millions spent developing and advertising for the superior safety profile of Celebrex and Vioxx–only to find an increasing risk of other types of conditions. This is the perfect example of the true guinea pigs of new drugs–the patients taking a new drug for the first decade or so of its use. When a new drug hits the open market this is the first time that particular drug has been used on such a large study and this is when the dangerous side effects often first appear.
The Journal : Current Issue –