Regulation of cell cycle 16a-hydroxyestrone in breast cancer cells – (12-31-01)



Regulation of cell cycle 16a-hydroxyestrone in breast cancer cells

The breakdown of estradiol (one of the three circulating estrogens in humans) can yield several pathways. The 2- pathway is generally considered beneficial and anti-carcinogenic, while the 16 pathway is considered damaging and carcinogenic. Promotion of the 2 pathway over the 16 is aided by the intake of substances found in cruciferous vegetables. There are now functional medicine labs checking 2/16 hydroxylation ratio to assess a woman’s risk of breast cancer.

J S LEWIS et al.: 16a-Hydroxyestrone and cell cycle regulation (Journal of Molecular Endocrinology)

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For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.







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