Reduction in Type 2 Diabetes with Lifestyle vs Metformin
I must say the the pharmaceuticals are trying to figure out how this one got out! Lifestyle intervention was more effective than metformin for lowering conversion from high risk to diabetic. The other beautiful thing is that lifestyle intervention also reduces risk of a huge list of other chronic and acute diseases with NO side effects. Metformin, on the other hand, can affect the liver and can produce life threatening metabolic acidosis. Which would you pick?
NEJM — Abstracts: Diabetes Prevention Program Research Group 346 (6): 393