The data coming out of non-steroidal anti-inflammatory drugs (like ibuprofen) and the risk of heart attacks is downright scary. All of this was precipitated by the lawsuit against Merck because of their suppression of data that the blockbuster drug Vioxx was causing heart attacks. This prompted researchers to look at other NSAIDs and the data is very consistent.
In addition to bleeding ulcers, dementia, liver damage, kidney damage, joint damage and impotence, this class of drugs is absolutely, positively NOT to be used in anyone with heart disease. This would include the >50% of the population that is prediabetic.
But this is, of course, only for people who use these drugs for months and years at a stretch, right? According to this study, DAY ONE was soon enough to cause a heart attack or death in patients who had pre-existing heart disease. Day one. The particular NSAIDs that was the worst was diclonfenac, a drug that I see given to patients for simple musculoskeletal problems far too often.
Bottom line is that there are no safe drugs for pain, either prescription or over the counter. Being somewhat biased towards chiropractic care, I would have to strongly suggest that a visit a chiropractor in Mesa is warranted even before you pop that ibuprofen or Tylenol.