Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands – (03-10-03)

Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: Evidence for an antiinflammatory role for lipoprotein lipase.

Sorry for the long, biochemically title, but it’s good for shock value. PPAR receptors are a group of genes that produce proteins that seem to have a beneficial impact on insulin sensitivity and inflammation (there are at least 3 known classes of PPAR receptors). So, anything that could increase PPAR expression (this type of substance would be called a ligand) has a potential to influence disease processes. Conjugated linoleic acid is known to act as a PPAR ligand as well. The interesting thing about this article is the lipoprotein lipase is known to have several genetic polymorphisms, meaning that this enzyme can run at different speeds in different patients depending upon their genetic makeup. This genetic makeup is easily determined by new tests that identify groups of polymorphisms.

PNAS — Abstracts: Ziouzenkova et al. 100 (5): 2730

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.