Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells
We’re back to my future book “Mitochondrial dysfunction as the root of all chronic disease.” Not quite sure if that title is going to catapult the book to the New York Times bestseller list, though. Anyway, I have mentioned many times before that cholesterol does not do damage to our vessels until it gets damaged, usually through inflammation or oxidative stress.
Now we are starting to identify the pathway by which this oxidized LDL particle creates damage to the vessel wall. And guess what comes to the forefront. You guessed it–mitochondrial induced oxidative stress. Mammalian health and disease is such an incredible, connected labyrinth.
So, natural approaches to lower the risk of CVD. Do they act by protecting the LDL molecule or protecting the mitochondria from initiating the damage caused by oxLDL? Most likely the answer is both.