L monocytogenes infection as complication of TNF alpha blockade.
I know that, to many patients with autoimmune conditions like Crohns and RA, these drugs can work miracles. However, many (if not most) of the patients on these drugs have never been given a strong trial of lifestyle changes (lowering of insulin levels, obesity reduction, increased intakes of fish oils and fruits and veggies) to affect their diseases. The newest type of drug to manage these conditions are TNF alpha blockers. However, TNF alpha is an essential aspect of the immune system and is needed to fight off infections and cancer. I know that, as these drugs are on the market longer and longer, we will begin to see some of the truly damaging effects of TNF alpha lowering.