Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice
While this is a mouse study, it does add weight to the concept of calorie restriction without nutrient restriction as being a viable tool for improving health and lowering risk of chronic disease.
This particular study compared calorie restriction with alternate day calorie restriction (50% less calories every other day) and found the impact on markers of CVD risk similar. This is very important, because alternate day calorie restriction is an approach that many people would find acceptable for long term risk management.