Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
The whole idea that every patient can be treated with blanket recommendations and everyone has the same RDI for vitamins has become old hat. We now have identifed many genetic uniquenesses that correlate with risk of disease process.
This study found a specific genotype that was at greater risk of inflammation from too much omega-6 vs omega-3. What happens if we go back to the ideas of the old research studies in light of what we now know? Will those studies evaluating fat intake and chronic disease show a striking increase in risk if we stratify for these genetic uniquenesses?? I would believe strongly that this would be the case.
NEJM — Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis –