Fructose Reduces Circulating Insulin and Leptin, Attenuates Postprandial Suppression of Ghrelin, and Increases Triglycerides in Women
This has been a tough one to explain. Research has shown that fructose (as in high fructose corn syrup) has little effect on insulin levels. This would, at first glance, make it seem a-ok from a dietary standpoint. But most functional medicine practioners have recommended avoiding it for a long time now.
This article starts to shed some light on the harms of this dietary factor. Basically, fructose does not effect insulin, but it does affect leptin and ghrelin in a negative way. Lower leptin levels were seen (remember that leptin speeds up metabolism and suppresses hunger) and higher ghrelin levels (ghrelin will stimulate appretite) in the participants fed high fructose diets. This could definitely lead to weight issues.
JCEM — Abstracts: Teff et al. 89 (6): 2963 –