Effect of low doses of 5-methyltetrahydrofolate and folic acid – (09-26-02)

Effect of low doses of 5-methyltetrahydrofolate and folic acid on plasma homocysteine in healthy subjects with or without the 677CT polymorphism of methylenetetrahydrofolate reductase

Sorry about the long title…This study compares the use of folic acid to 5-methyl THF, the active form of folic acid (after being converted by MTHFR). Both showed similar effects at lowering homocysteine. However, the interesting effect here is that, in patients with two sluggish copies of the enzyme MTHFR, 5-methyl THF showed continued lowering of homocysteine 6 month after cessation of supplementation. This suggests that 5-methyl THF supplementation somehow changed the phenotypic expression related to folic acid metabolism.

Synergy Abstract

Read entire article here

James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.