Dietary nitrate, mutagenic concentrations of NO at the GE junction.

Now this is a convoluted pathway…we eat processed meats high in nitrates. This gets absorbed in the GI tract and makes it back to the saliva where bacteria in the mouth convert the nitrate to nitrite. The nitrite is swallowed and turned to nitric oxide by gastric juice. This elevated nitric oxide is believed to be a contributing factor to cancer risk in the upper stomach and lower esophagus. Talk about a physiology/biochemistry lesson!! Just remember this next time you are about to take a bite of processed meat…

Gastroenterology Online –

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.