Demyelination occurring during anti-TNF alpha therapy
With the increasing use of TNF-alpha blockade I am sure we are going to see an increase in the side effects; some of which may be unforeseen and dangerous. When you begin to mess with one of the fundamental cytokines for inflammation we can not even begin to imagine the downstream effects. Natural routes of TNF-alpha reduction would include weight loss, lowering of hyperinsulinemia, antioxidant therapy, and possibly the reduction of LPS (antigenic compounds from bad bacteria) via restoration of a healthy GI environment.