Glucocorticoids and Relapse of Major Depression
This topic is always a tough one. Most therapists never view the physiological contribution to psychological disorders, but the evidence is strongly in support of a link.
This article finds that, in those patients with an exaggerated CRH stimulation test producing too much cortisol, the likelihood of a relapse was higher. This wold indicate that the patient who relapsed had adrenal glands that were not working properly, and were improperly producing too much cortisol rather than a balance of DHEA, aldosterone and cortisol.