Thiazolidinedione Use and Bone Loss in Older Diabetic Adults
Avandia and Actose are a class of diabetic drugs known as TZDs that act on the PPAR gamma receptor. Unfortunately, like every other drug out there, they have some long lists of side effects.
This particular study looks at the bone damaging effect of these drugs. Interestingly, while sticking with the near-Vitamin-D-worship status of this Updates, Vit D not only protects bones but also helps manage insulin resistance, a precursor to diabetes. You can also add exercise to that list as well. So basically, the approaches we should be taking that involve diet and lifestyle will lower the risk of diabetes while protecting the bones. This class of drugs, however, actually contributes to more bone loss the longer you’re on them. Would SEEM like a no-brainer, huh?