BH4, A COFACTOR IN THE ACTIVATION OF NITRIC OXIDE SYNTHASE (NOS) (02-23-09)

Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin. Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy

Personally, I think that “tetrahydrobiopterin” is a wonderful word to use in daily conversion and will not only score big points in Scrabble, but will make you appear much smarter. Boiling it down to a physiologic level, BH4 is a cofactor that is involved in some very important processes, including the production of neurotransmitters involved in mood and energy, as well as the activation of nitric oxide synthase (NOS). Remember that NOS is an enzyme that produces, nitric oxide, and that nitric oxide helps to relax blood vessels and make blood vessels happier.

So this study finds that the use of BH4 has a positive effect on the function of the heart muscles. Another important thing to consider is that, for proper formation of BH4 to occur, the body has to be able to methylate properly–which requires adequate levels of folic acid, B12 and B6 and is highly effected by genetic uniquenesses.

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For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.







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