Avandia has been in use for over 15 years. It was launched around the same time that another drug in the same class (PPAR-agonists…Rezulin) was pulled from the market due to liver failure.
Over time, this rapidly-adopted “blockbuster drug” began to accumulate evidence that Avandia greatly increases the risk of heart disease. Given that 70% of diabetics already die from heart disease, one would think this would be a concern.
The bottom line is that, while this class of drugs makes your blood sugar numbers look better, it creates many more problems than it solves.
Lifestyle changes remain the only answer that doesn’t kill you first.