Analgesic use: Predictor of chronic pain, medication overuse headache
The results of this study find that in patients with heavy analgesic use, they were more likely to experience chronic pain 11 years later. This is not really a big surprise since it is well known that NSAIDs inhibit proper healing of connective tissue. Consider a patient on long term NSAIDs that sustains an injury. The injury never properly heals because of the block to normal healing. We know have a tissue that is prone to injury, setting up the cycle for further injury and NSAID use.
Neurology — Abstracts: Zwart et al. 61 (2): 160