***Protective effect of vanadyl sulfate on the pancreas of streptozotocin-induced diabetic rats***
Ok, so it's a rat study, but it's still pretty significant that vanadium in this study was not only able to protect the beta cells of the pancreas (the cells that make insulin), but also may be able to regenerate the cells!! That's something that mainstream medicine is trying to do w/ beta cell transplants, with minimal results. Of course, maybe we'd need less regeneration if we could quit using the sulfonurea diabetic drugs like Glucotrol that are known to destroy the beta cells of the pancreas.
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***Effects of Conjugated Equine Estrogen on Health-Related Quality of Life in Postmenopausal Women With Hysterectomy***
With a little hope, this may truly be the end of the era of HRT for women. It began in the 60s as a published case study series of one clinician, and, with no evidence to support it, bloomed into one of the largest money makers the drug companies have ever known. The safety studies were never done until the WHI studies several years ago. Never done. Just remember this when you think that the FDA and the drug companies are operating in the best interest of the patient.
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***Diverticular Disease: Diagnosis and Treatment***
Diverticulitis is a condition that I see occasionally in practice. While antibiotics are important in the acute management of the condition, recommendations to avoid flare ups seem a little sparse for most patients. Almost always, patients have been told to avoid foods with small seeds, but patients rarely note that this is an inflamming activity, and no evidence exists to support this restriction. High fiber diets, on the other hand, do have evidence to support their use. While this article does not mention probiotics, the studies showing overall positive benefit of probiotic supplementation on GI complaints are numerous.
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***A transient treatment of hippocampal neurons with alpha-tocopherol induces a long-lasting protection against oxidative damage via a genomic action***
While this is a rat study, it does illustrate the potential problems that the recent attempt to scare everyone away from Vit E may have. Thousands of studies have shown a benefit for Vit E (normally given as alpha tocopherol) for a variety of conditions, and yet a recent review of a handful of studies reviewing ONLY alpha tocopherol supplementation (which is not recommended anyway--should give a mixed tocopherol product along w/ additional antioxidants such as Vit C) showed a very small potential increase in harm. In this study, Vit E actually provided long lasting protection by changing the way the genes were being expressed.
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***Prescriptions for Chronic High-Dose Cyclooxygenase-2 Inhibitors are Often Inappropriate and Potentially Dangerous***
How much MORE apparent does it have to be that physicians are not reading their own literature? We've learned that the COX-2 class of drugs is very expensive, has minimal benefit over other NSAIDs and has significant cardiovascular risk, and yet there're STILL being used inappropriately!! Good to know that the drug reps are earning their commissions...
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***Signs of chronic stress in women with recurrent candida vulvovaginitis***
While we offhandedly use the phrase "stress kills" we don't often think of how accurate that phrase is. Much like insulin resistance and lack of exercise, stress is always there underlying much of the pathology that we experience. In this case, women with recurrent vaginal yeast infections had a lowered morning cortisol level (levels should be highest in AM and taper to their lowest just before sleep), indicative of chronic stress. So, the best management for these patients would be stress management and probiotics to restore the normal, competetive flora that should be present in the vaginal vault. Without addressing the underlying causes, oral and topical anti-fungals will only act as a band aid.
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***gamma-Glutamyltransferase as a Risk Factor for Cardiovascular Disease Mortality***
GGT is normally thought of as a marker of liver or gall bladder dysfunction (it is called a liver "function" test, but is actually looked for dead cells spilling more of the enzymes into the bloodstream--hardly a marker of "function" if you ask me...), but has been gaining increased popularity as a marker of CVD and insulin resistance. So, chalk yet another marker up for risk of insulin resistance and CVD. One thing I have not seen mentioned, however, is whether the relationship is direct or indirect. Insulin resistance is known to cause an elevation of liver enzymes and non-alcoholic steatohepatitis (or called non-alcoholic fatty liver disease- NAFLD). So, is this just another marker of the damage that insulin resistance is doing, or does the GGT have a direct relationship to CVD? And does it matter??
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***Association of Amoxicillin Use During Early Childhood With Developmental Tooth Enamel Defects***
While the relationship to dental problems is not a big surprise, the number of infants that recieved a prescription for amoxicillin in this study by age 32 months is a mind blowing, staggering 91%. How did we ever survive the past million years without antibiotics? It's a good thing we have astute pediatricians with concern for destruction of normal flora with antibiotics and the havoc that destruction can wreak on a naive immune system...
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***Dismissing the Family Who Refuses Vaccines***
This is interesting. Vaccination is viewed as preventative by the medical profession. So refusal of a preventative approach is devasting enough to the doctor patient relationship to cancel that relationship. Okay. Let's run the survery again. How many pediatricians would dismiss their patients who refuse to stop feeding their children refined carbs? Refined carbs are devasting to a child's health and longevity to a degree that dwarfs vaccination preventable diseases. We can all guess the results. So why selectively dismiss patients whose parents refuse vaccination, but at the same time not aggressively pursue and recommend avoidance of other behaviors much more damaging? And without the potential downside that vaccination can have in genetically suseptable individuals...
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***Normal Fasting Plasma Glucose Levels and Type 2 Diabetes in Young Men***
Remember that progression to diabetes is a continuum--a patient is not normal on Thurs and then diabetic on Friday when their labs finally tip over to abnormal. I can't tell you how many patients come through my office with elevated triglycerides, low HDL, elevated LDL, hypertension, abdominal obesity and strong family history of diabetes and CVD, and tell me that they're not diabetic because their family doc checked "that." If physicians learned what to look for, we could be catching these patients literally DECADES before they get a diagnosis of diabetes or have their first heart attack, and starting them on a lifestyle management program. But alas, the status quo prevails...
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James Bogash, DC and Amy Strock, DC
1830 S. Alma School Rd, Bldg 7, Ste 135, Mesa, AZ 85210
(Alma School Road, just south of the Superstition Freeway/Highway 60)
Chiropractic Health Care Chandler, Mesa, Gilbert & Tempe, Arizona
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