Research Updates 3-6-2005
***Bacterial counts of intestinal Lactobacillus species in infants with colic***
There is no longer a question that the bacterial flora in our bodies (pharynx, stomach, SI, LI, vaginal vault..) have an impact on our health. While many clinicians that wouldn't recognize a medical journal if it hit them in the face remains oblivious to this fact, the research, as always, moves on. We are now focusing on the types and levels of bacteria that positively and negatively impact our health. Considering the number of bacteria in our gut, this job is not an easy one. The research comes in in bits and pieces, but I'm sure that we will soon have a much clearer picture of the impacts different species have on our health. Maybe then our focus will shift away from antibiotic resistance to the much larger problem of destroying normal, protective flora.
***Origins, evolution of the Western diet: health implications for the 21st century***
While this article probably adds nothing new to your knowledge base, the quote "The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization" is wonderful. "Collision" is probably the best description!
***Direct comparison of dietary portfolio of cholesterol-lowering foods with a statin***
Hmmm...over a quarter of the patients in this study achieved BETTER lowering with the diet. All patients benefitted at least as well with the diet as with the drug. So, the benefits are equal--why not just take the drug? Simply because the dietary intervention has also lowered the risk for any number of other chronic diseases. The statin drug has just effected cholesterol (and even this is questionable for lowering risk of cardiac deaths) and may actually INCREASE your risk of other diseases by lowering CoQ10 production.
***Parent Opinions About Universal Influenza Vaccination for Infants, Toddlers***
It always seems interesting. Across the board, every survey ever looking at vaccination that I have come across shows more educated parents having lower rates of vaccination. Now why do you think that is?
***Periodontal Microbiota and Carotid Intima-Media Thickness***
This is by no means the first article linking dental health and cardiovascular risk. Whether it is a direct seeding of the bacteria into the bloodstream, an indirect upregulation of the immune process fighting off the bacteria in the gums or a reflection of the overall health of the person has yet to be determined. What we do know is that dentists have the opportunity to intervene/identify patients at increased risk of CVD.
***Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents***
I have a patient that has seizures and of the providers and specialists and relatives' friend who are doctors all have just one answer--anti seizure medications. While these drugs do not effect the underlying process that is causing the seizures (all research is pointing towards a mitochondrial/oxidative stress model of many neurological disorders) they do have a long list of side effects--and on average--a 30% efficacy. One of the concerns of many epileptics is the risk of sudden unexplained death in epilepsy (SUDE). Wouldn't that be a kick in the pants if the medications for epilepsy are actually a major causative factor in SUDE?
***Relation of depressive symptoms to CRP and pathogen burden (cytomegalovirus, herpes simplex virus, Epstein-Barr virus) in patients w/ earlier acute coronary syndromes***
This article has so many implications. And it is a perfect example of why so much research into "CAM therapies" or natural approaches bothers me. The finding of strong relationships between both being depressed and/or having a latent viral infection with elevated CRP levels adds yet another layer to the onion that is cardiovascular disease. Mainstream medicine has always tried to follow the "one cause, one cure" model but it fails miserably for chronic diseases. Any natural approach to CVD addresses a multitude of lifestyle and nutritional interventions. And yes, addressing psychological health is a part of that approach. What I would love to see now is, do antidepressant medications lower CRP levels? Or do they mask the symptoms and allow underlying damaging physiological imbalances to continue...
***A “poly-portfolio” for secondary prevention: A strategy to reduce subsequent events by up to 97% over five years***
Ooops. I stand corrected. Mainstream medicine really is dumping the "one cause, one cure" model. See--here they have combined multiple medications into a single pill to achieve a 97% CVD reduction. However, this article does not note the some odd 10-20% of the patients that will have an adverse reaction to this polypill...
***Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn’s disease***
It is strange that two of strongest markers to predict relapse are tests most GI docs have probably never heard of. Altered GI permeability ("leaky gut") as evidenced by a lactulose/mannitol challenge is another strong predictor of relapse. The nice thing is that these markers can be easily checked and modified with natural approaches such as omega-3 fatty acids, non-processed diets and probiotic supplementation.
***Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise***
For many years, conditions like chronic fatigue and irritable bowel were considered psychogenic because no physiological alterations could be found. Well, it's not that they weren't there--we just didn't know where to look. This study just confirms what many of us in manual medicine have known for some time--these patients are very prone to "overtreatment." Do too much, exercise too much or go too deep and the patient will be very sore the next day. Following the results of this article, it is logical to assume that these patients would respond very favorable to interventions designed to support the mitochodria and reduce oxidative stress.
James Bogash, DC and Amy Strock, DC
1830 S. Alma School Rd, Bldg 7, Ste 135, Mesa, AZ 85210
(Alma School Road, just south of the Superstition Freeway/Highway 60)
Chiropractic Health Care Chandler, Mesa, Gilbert & Tempe, Arizona
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