Direct toxicity of NSAIDS for renal medullary cells
Much attention has been focused on the gastrointestinal side effects of NSAIDs, but frequently the damaging effects on the liver, kidneys and joints are never mentioned. An article that appeared in the NEJM several years back gave a LIFETIME accumulation of effects from NSAIDs and acetominophen. 5000 NSAIDs over a lifetime increased risk of renal failure by several fold. How many of us hit this by the time we’re 20?
PNAS — Abstracts: Rocha et al. 98 (9): 5317