***Relationship between Urinary 15-F2t-Isoprostane and 8-Oxodeoxyguanosine Levels and Breast Cancer Risk***
If you can pronounce the above, you're already way ahead of the game. Here's the basics. Damage certain areas of DNA and you get 5-oxoDG. Too much damage, and, the next time that cell divides, you could get cancer. Too much damaging free radicals hanging around unsaturated fatty acids and those fats can go rancid, leading to F2 isoprostanes. So what does this mean? Lifestyles that will increase free radical generation (smoking, sedentary lifestyle, stress, processed food) and a diet poor in protective factors (fruits, veggies, spices...) will result in damage to your DNA. Plain and simple. This damage will then increase your risk of cancer. http://cebp.aacrjournals.org/cgi/content/abstract/15/4/639

***The Relationship between Green Tea and Total Caffeine Intake and Risk for Self-Reported Type 2 Diabetes***
I didn't see Starbuck's listed as providing funding for this study so it's got a little more credibility. I personally feel that coffee got a bad rap in the past, not because it wasn't good for us, but rather because it was associated with many unhealthy behaviors such as skipping breakfast and cigarette smoking. This study decided to take a look at the caffeine in green tea as well and found that coffee (>3 cups/day) and green tea (>6 cups/day) gave a 33% reduction in diabetes risk. This association did not hold true for black or oolong tea, though. http://www.annals.org/cgi/content/abstract/144/8/554

***Prevalence of unexplained upper abdominal symptoms in patients with migraine***
Looking at recent literature on migraines, it becomes evident that we are approaching treatment from the completely wrong angle. Migraines are slowly being recognized as manifestions of dysfunction in the entire body. Oxidative stress. Toxin overload. Mitochondrial dysfunction. The medications used to treat migraines in no way address these factors. The best approach to migraines involves lifestyle changes to impact the systemic problem. If uncorrected, migraine patients have a higher risk of stroke and neurodegenerative disorders. This article supports the systemic links w/ migraine, suggesting that migraineurs have higher likelihood of having digestive complaints. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1468-2982.2005.01076.x

***Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic Medication***
A concert with the previous article, this one again suggests that there is an underlying mechanisms to migraines that is NOT being address by physicians treated patients for migraine headaches. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1526-4610.2006.00454.x

***Migraine Headaches and Preeclampsia: An Epidemiologic Review***
Are we getting the point? To further illustrate my point, preeclampsia risk has been shown to go down with higher intakes of vitamins C and E (again--antioxidants that can help protect the mitochondria). So, patients with migraines that are actually an outward manifestation of oxidative stress/mitochondrial dysfunction, are not ever told how to properly address their condition. This then leaves these patients at increased risk of preeclampsia and then later for stroke and neurodegenerative disorders. Our current approach to migraines is clearly the wrong approach. http://www.blackwell-synergy.com/doi/abs/10.1111/j.1526-4610.2006.00432.x

***Errors that result from using the TC/HDL C ratio rather than the apoB/apoA-I ratio to identify the lipoprotein-related risk of vascular disease***
Wow. Sometimes we really hit articles that remind us how far we can fall behind in the research. Most physicians are still blissfully making clinical decisions based entirely on total cholesterol. Some even take HDL into account. Smaller still are the physicians recognizing the risk that triglycerides/HDL ratio play. So, while most physicians are decades behind using tri/HDL ratios, research is finding that apoB/apo A-1 ratios are much, much stronger at predicting CVD risk. Just when mainstream medicine might have been catching up... http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2796.2006.01649.x

***Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen***
I guess this is "long title" week.. It is well known that the NSAID class of drugs is responsible for as many as 21,000 deaths per year. Most of these occur due to fatal GI bleeds. Misoprostol is a drug given along with certain NSAIDs to try to lower the damage done to the lining of the GI tract. Which, of course, has its own set of side effects. This study finds a powerful ability of curcumin, one of the spices found in turmeric (used in mustard), to protect the GI tract from damage caused by indomethicin. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4J2CMTY-1&_coverDate=04%2F15%2F2006&_alid=393408469&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4940&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=dbff9e1fbfb990876626bd0900a6c29b

***Antioxidant α-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-κB ligand and tumor necrosis factor-alpha***
I admit it. I've got a thing for long, technical titles. Our view of osteoporosis is changing dramatically (at least in the research) and inflammation plays a major role in this. Basically, the more the inflammation, the higher number of cells that break down bone. Too many osteoclasts breaking down bone in comparison to osteoblasts buidling bone, and you lose bone too quickly. So anything that lowers inflammation will have a positive effect on bone. So, this article looked at the ability of alpha lipoic acid to reduce oxidative stress and reduce the number of osteoclasts. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4HS3GG6-2&_coverDate=05%2F01%2F2006&_alid=393632965&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4940&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=37fbb545032b3446bf034f451ab00c44

***Periodontal infections cause changes in traditional and novel cardiovascular risk factors***
Again, we see how much any source of chronic inflammation can play a large role in cardiovascular disease. I would also assume that those with poor dental health probably aren't too concerned with their overall health, either. One thing to consider in addition to treatment for periodontal disease would be using xylitol containing gum. This sugar is believed to change to physiology of the bacteria in the oral cavity, leaving them less likely to cause dental caries and subsequent infections. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6W9H-4JTJ7J3-G&_coverDate=05%2F31%2F2006&_alid=395680180&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=6683&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=739fbf88f42823ef723b351b423c1ab8

***Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo***
I feel that our fear-mongering with sunlight exposure and skin cancer has done more harm than good (as usual...). Instead of focusing on rational sun exposure and the implications that a poor quality diet can increase the risk for skin cancers, we tell people to slap on SPF 75 to walk to the car. The result? Still no focus on the fault of low intakes of healthier fats on the increase in melanoma in kids (do you think today's kids get more or less sun exposure??) and endemic levels of Vit D deficiency. This article again supports the concepts that healthy fats have a large contribution to the general health of our skin. http://www.jlr.org/cgi/content/abstract/47/5/921

James Bogash, DC and Amy Strock, DC
1830 S. Alma School Rd, Bldg 7, Ste 135, Mesa, AZ 85210
(Alma School Road, just south of the Superstition Freeway/Highway 60)
Chiropractic Health Care Chandler, Mesa, Gilbert & Tempe, Arizona
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